Job Description
Senior Scientist / Principal Scientist, Bioprocess Sciences
Location: San Diego
Job Type: Full?Time
About Us: A stealth?mode biotech focused on developing best?in?class delivery for in?vivo gene editing.
Job Summary: We are seeking a highly motivated and experienced scientific expert to join our team as a Senior Scientist or Principal Scientist of Bioprocess Sciences. This role will provide technical expertise for bacterial protein production programs supporting research and development. The successful candidate will be part of a dynamic team of scientists responsible for process development, scale?up strategy and external manufacturing oversight. Title and compensation will be commensurate with experience.
Key Responsibilities
- Provide technical expertise for bacterial strain engineering, fermentation, protein expression, purification, and protein characterization activities.
- Develop, optimize, and scale bacterial culture and purification processes for internal and external manufacturing.
- Manage and oversee activities at contract development and manufacturing organizations (CDMOs), including tech transfer, process troubleshooting, timelines, and deliverables.
- Partner cross?functionally with research, analytical, quality, and leadership teams to achieve project milestones.
- Establish and maintain robust documentation, protocols, and data packages to support internal decision?making and external partners.
- Prepare and present technical reports, development strategies, and risk assessments to internal stakeholders.
- Stay current with advancements in bioprocessing technologies, manufacturing trends, and regulatory expectations.
Qualifications
- D. degree in Chemistry, Biology, Biochemistry, Biomedical Engineering, Chemical Engineering, or a related field.
- 6+ years of progressive experience in bacterial protein expression, purification, and bioprocess development.
- Demonstrated experience leading projects and mentoring or managing scientists.
- Hands?on expertise with affinity?based protein purification (e.g., FPLC), bacterial expression systems, and routine molecular biology assays.
- Strong working knowledge of SDS?PAGE, Western blotting, ELISA, and other biochemical and biophysical assays.
- Experience interpreting QC assays (fluorometric, chromogenic, etc.) and assessing data quality and process performance.
- Routine use of electronic laboratory notebooks (e.g., Benchling) with a strong commitment to data integrity.
- Excellent analytical, communication, and organizational skills with the ability to manage multiple priorities.
- Ability to work independently in a fast?paced, evolving environment.
Preferred Qualifications
- Direct experience managing or collaborating with CDMOs for process development or manufacturing.
- Experience with bioreactor operations, scale?up, and tech transfer.
- Protein characterization experience using HPLC/UPLC and/or LC?MS.
- Familiarity with regulatory expectations related to bioprocessing and manufacturing.
- Background in protein engineering or recombinant protein production.
Benefits
- Competitive salary, equity, and comprehensive benefits package.
- Opportunities for professional growth and leadership development.
- Fast?paced, collaborative, and innovative work environment.
How to Apply
Interested candidates should submit their resume and a cover letter detailing relevant experience. To be considered for the role, applicants must be:
- Eligible to work in the United States for any employer without sponsorship.
- Able to work onsite in the lab located in San Diego.
- A direct candidate and not from a third party, i.e., staffing agency.
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Job Tags
Full time, Contract work,